The Global Alliance in Acute and Long-Term outcome https://genestroke.wixsite.com/alliesinstroke is an initiative of researchers from the International Stroke Genetics Consortium (ISGC) interested in the genetics associated with the neurological evolution and the stroke long-term recovery. This global initiative is open to researchers that are recruiting or will recruit ischemic stroke patients prospectively. For more information please send an e-mail through our Contact section. The Global Alliance group is Chaired by Prof Arne Lindgren and Dr Israel Fernández Cadenas and is leading the harmonization of stroke outcome measures across member sites.
The Genetics of Stroke Functional Outcome (GISCOME) network now sits within the Global Alliance, and is tri-led by Prof Christina Jern, Prof Arne Lindgren and Prof Jane Maguire. The aim of this network, established in 2012 was to investigate the genetic influences on stroke outcomes, with a focus on functional ability. In phase 1, the GISCOME investigators established the world’s first genome wide association (GWA) genetic dataset for functional outcome of ischemic stroke and reported the first GWAs significant variant for this phenotype. In 2025, Phase-2 is nearing completion and has identified over 20,000 retrospective cases with the aim to meta-analyse and replicate the phase1 result. This is an ongoing collaboration, and all are welcome to join this group.
