Dr. Guido J. Falcone is a Neurologist with subspecialty training in Neurocritical Care and Stroke, and an Epidemiologist with expertise in Population Genetics and Big Data. His research lies at the interphase of clinical neurology, neuroimaging, population and medical genetics, and Big Data. Dr. Falcone is interested in understanding how common and rare genetic variation influences the occurrence, severity, functional outcome, and recurrence of stroke, both hemorrhagic and ischemic. Genetic variants influencing these phenotypes can be used for numerous applications, including: (1) identification of novel biological mechanisms involved in causing stroke and determining its severity and outcome, (2) answering non-genetic epidemiological questions using gene mutations as instruments (in the statistical sense of the word), and (3) risk stratification of patients according to their genetic profile. Through the International Stroke Genetics Consortium, He works in close collaboration with numerous investigators interested in stroke genomics from around the world