Translational Research Working Group

Chair / Co-Chairs: Christopher D. Anderson and Tom Van Agtmael

The Translational Research Working Group (TRWG) of the International Stroke Genetics Consortium (ISGC) is a group of statistical and molecular geneticists, molecular and cell biologists, model-systems specialists, and neurologists who share the common goal of linking genetic discoveries in stroke and cerebrovascular disease to molecular signatures, biological pathways, and ultimately drug targets. Because genome-wide discoveries tag regions of DNA rather than genes or causal mechanisms, it is critical that these findings are shared among multidisciplinary scientists who can design studies to help identify their relevance and mechanism, and how they might be harnessed to design therapeutic strategies to improve the lives of individuals and families affected by stroke and its many chronic cerebrovascular manifestations. The TRWG is in the process of developing an on-line forum where ISGC members can share discoveries and questions in a cross-disciplinary fashion to determine the best next steps for follow-up research and establish collaborations with researchers interested in working together to perform translational studies. Examples of current projects include fine mapping and annotation of genome-wide loci in intracerebral hemorrhage and cerebral small vessel disease, defining cell-specific signatures in familial and sporadic forms of collagen vascular disease, and developing and utilizing animal models of small vessel disease, microinfarcts and hemorrhage in sickle cell disease, etc. We are always open to discuss and exploit new opportunities, so if you would like to join us or discuss any opportunities for future project please get in touch.