This section contains links to general ISGC documents, minutes of previous meetings, the ISGC newsletter and links to meeting presentations where slides have been made available by speakers.
ISGC Career Development Scholarship
Thanks to the generosity of an anonymous donor, we have been able to offer one or two scholarships per year since 2010. These scholarships award up to $500 to a junior researcher to contribute towards attendance of an ISGC meeting or meeting relating to stroke and/or genetics. Given the nature of the funding, future calls will be announced here if appropriate as well as by e-mail to the entire ISGC – please check back regularly for updates.
ISGC Newsletters
The ISGC publishes two bi-monthly newsletter for members. One relates to all ISGC activities and the second is haemorrhage specific. These newsletters contain updates on existing projects, list new project calls and ISGC meeting related information. As well as being circulated on the ISGC e-mail list, copies of all news letters are available below, most recent publication first.
ISGC newsletters
ISGC Outreach Committee Documents
Letter of invitation May 2014 – blank
Letter of invitation May 2014 – with content
Letter on invitation July 2014 – blank
Letter of Invitation Dec 2014 – doc
Letter of Invitation Dec 2014 – pdf
Website welcome letter Dec 2014 – doc
Minutes from past meetings
ISGC meetings since the 5th International workshop in Munich have not been so formal and minutes are no longer taken. For reference, minutes from the first 5 meetings of the ISGC are below.
1st International ISGC Workshop – London, Spring 2007
2nd International ISGC Workshop – Baltimore, Autumn 2007
Intermediary ISGC Workshop – New Orleans, January 2008
3rd International Workshop – Nice, Spring 2008
4th International Workshop – Boston, Autumn 2008
5th International Workshop – Munich, Summer 2009
Meeting Presentation Slides
These are links to slides used at previous ISGC workshops. It is strongly recommended you ‘right mouse click’ and select ‘save target as…’ to obtain the files. Simply clicking on the link to open the files may freeze your browser. Availability of slides from meetings is dependent upon both the host venue and speakers making slides available. Not all meetings have been able to collate presentations in this way – all those that are available are on this website.
Paris – Autumn 2014
Chairs welcome address – J Maguire
CVT exome arrary analysis – I Cotlarciuc
Metastroke 1000 genomes imputation results – R Malik
GISCOME phenotype manuscript – J Maguire
Age at onset informed analysis of ischaemic stroke GWAS – M Traylor
Agnostic approaches to decipher determinants of cervical artery dissection – S Debette
GWAS of brain microbleeds, the CHARGE consortium – A Ikram
Monogenic cerebral small vessel disease, a historical perspective – E Tournire-Lasserve
GISCOME interim results – S Bevan
Genetic architecture of small veseel disease – H Markus
Partial derivatives meta-analysis – A Ikram
IDeA lab projects – P Maillard
Heritability of ischaemic white matter lesions – P Nyquist
Stroke prone rat to cerebral small vessel disease in the general population – J Perra
Latent TGF-B binding protein 1 – a new player in familial small vessel disease – C Haffner
Neuroimaging working group update – N Rost
Trans-ethnic GWAS of MRI-defined brain infarcts, the CHARGE consortium – G Chauhan
WMH in ischaemic stroke GWAS study collaboration – M Traylor
ICH meta-analysis update – J Rosand
Sifap WMH GWAS in young stroke – A-K Giese
SiGN GWAS of ischaemic stroke and its subtypes – S Pulit
Outreach committee report – J Majersik
Targeted sequencing in sporadic lacounar stroke in the Lombardia region – A Bersano
Functional genomics in cardiovascular disease: lessons from hypertension – F Charchar
Searching for CNVs in patients with haemorrhagic stroke – I Lopes-Cendes
Association and meta-analysis strategies for rare variants – J Dupuis
CSF volumetric changes as a quantitative endophenotype of cerebral edema after stroke – R Dhar
Lesion localisation and genetics of stroke recovery – P Bentley
DNA methylation and cardiovascular phenotypes – D Tregouet
Genetics of early neurological improvement/deterioration after acute ischaemic stroke – L Heitsch
The genome of the Netherlands project – P de Bakker
Machine learning for stroke GWAS – L Wee
Associations of common varaition in COL4A1/COL4A2 with cerebral small vessel disease – K Rannikmae
Rare genetic disorders in young strokes – G Pare
Genetics of acute infarct lesions – N Rost
Mitochondria, mitochondrial DNA and stroke – M Mancuso
Translational working group update – G Falcone
Haemorrhagic transformation after rt-PA – I Fernandez-Cadenas
Acute endophenotypes working group – J-M Lee
Whole exome sequencing analysis of cerebral white matter hyperintensities on MRI – M Fornage
2014 general assembly and closing remarks – J Maguire
Salt Lake City – Spring 2014
Chairs welcome address – J Maguire
Rare Mendelian diseases: pathways to therapy development – S-M Pulst
Population based approaches to gene discovery – L Albright
Translational research working group – C Anderson
SiGN – GWAS of ischaemic stroke and its subtypes – S Pulit
Identifying additional samples for replication in SiGN – B Worrall
Big data approaches to stroke – J Rosand
SiGN pharmacogenomics proposal
Sex differences in stroke subtype and risk factors in SiGN – K Rexrode
The impact of diagnostic stroke tests on final etiological subtype assignment in SiGN – J Majersik
Update on ICH genetics – J Rosand and D Woo
ISGC/SiGN – REGARDS risk factor study – G Howard
Brazilian stroke biobank: Phase II genomic studies – N Cabral
Using extreme phenotypes to identify causal (and protective)) variants in ischaemic stroke – J Cole
1000 genome imputation update – R Malik
Identifying additional samples for ISGC expansion: aiming for 100k plus – B Worrall
Metastroke: Update – B Worrall
Meta-analysis of GWAS in intracranial aneurysms – Y Ruigrok
Brain and aortic aneurysm screening (BAAS) study – B Worrall
Genetics and posterior circulation in ischaemic stroke – A Lindgren
Neuroimaging working group update
Genetics of MRI phenotypes in acute stroke: potential impact and feasibility – V Thijs
Acute endophenpotypes working group
Genetics of ischaemic stroke functional outcome study: GISCOME – A Lindgren
GISCOME writing group – J Maguire
Baseline stroke severity (NIHSS) in GISCOME – J-M Lee
Multimodal outcome prediction in alteplase therapy – C Levi
ISGC 16th workshop: Paris – S Debette
Distribution of mRS scores in GISCOME – C Jern
Lund – Autumn 2013
Outreach committee presentation – A Slowik
SiGN analysis committee presentation – B Mitchell
Salt Lake City overview – J Majersik
The South American Network – J J Martin
Genetics of type II diabetes – pitfalls and possibilities – L Groop
Gene-environment interactions in cardiometabolic disease – M Orho-Melander
1000 Genomes imputation in METASTROKE – R Malik
SiGN administrative core update – S Kittner
Edinburgh – Summer 2010
Origins aims and achievements of the ISGC
A 4q25 variant and stroke in VSR
GWAS of IMT: Meta analysis from the CHARGE consortium
UK Biobank and common diseases
Australian Ischaemic Stroke GWAS
Can CTA and MRI predict response to treatment in ATACH II?
Career Development – the challenges and rewards of working in consortia
Association of MI associated SNPs with IS: a meta-analysis of 3 European Caucasian populations
Ethical and racial variations of Intracerebral Haemorrhage
Pharmacogenomics and stroke: the genetics and randomised trials network (GARNET)
Imaging methods for quantitative stroke related phenotypes
Genetic factors influencing outcome after stroke: systematic review and proposal
Genes and response to aspirin in secondary stroke prevention: GRASSP
GWAS of ICH meta-analysis – preliminary results
ICH GWAS – study update and preliminary analysis
Occult SVD in in high risk families
Association of GWAS based SNP variants with stroke: findings from the PAGE study
Genome wide gene expression in blood of patients with intracranial aneurysms
Report from the SouthWest Swedish Genetics Collaboration on stroke
Discovering ischaemic stroke genes: the first large GWAS studies and beyond
Genetics of early onset stroke
NINDS ischaemic stroke genetics consortium
RACE: risk assessment of cerebrovascular events
Cincinnati – Winter 2010
Introduction and Welcome – D Woo
Familial Intracranial Aneurysm Study – F Broderick
Consent Status and Phenotypic Characteristics in GOCHA – B Worrall
GWAS of Covert Brain Infarcts – S Debette
Genetics of Intracranial Aneurysms – F van ‘t Hof
Genes and Environment – C Langefeld
GWAS of WMH on MRI – M Fornage
Occult SVD in High Risk Patients – P Nyquist
Taiwan Stroke Registry – H-Y Chiou
Genetics of Cerebral Venous Thrombosis – P Sharma
Deep Cerebral Phenotypes – D Woo
ISGC Future Directions – D Woo
Global Gene Expression Profiles of Aneurysms – J Pera
Genetics of Early Onset Stroke Study – B Mitchell
Australian Stroke Genetics Collaborative – C Levi
Swedish Genetic Collaborative on Stroke – A Lindgren
Siblings with Ischaemic Stroke Study – J Meschia
Phenotype Harmonisation – S Bennett
9p21 Replication in a Chinese Cohort – X Wang
Munich – Summer 2009
Martin Dichgans – Wellcome, Introduction and Scene Setting
Stephanie Debette – CADISP Update
Paul Nyquist – Occult SVD In High Risk Families
John Attia – Australian Stroke Genetics Collaborative
Brad Worrall – 20 Chart Project
Brad Worrall – Consent Status Analysis
Boston – Autumn 2008
Lynelle Cortellini – ISGC website
Arne Lindgren & Steven Kittner – Standardising prospective data collection 1
Arne Lindgren & Steven Kittner – Standardising prospective data collection 2
Arne Lindgren & Steven Kittner – Minimum data set requirements
Paul de Bakker – Future considerations in GWAS